Welcome to the Larschan Lab at Brown University
We are developing innovative approaches to understanding how dosage compensation in Drosophila is established, the critical first step in coordinating regulation.
By combining genetic, biochemical, and genomic approaches, we will address the following key overall question: How are global and gene-specific transcriptional regulatory signals integrated to precisely regulate genes?
Our model
Drosophila, like mammals, increase the transcript levels of a large number of diversely-regulated genes along the length of the single male X-chromosome precisely two-fold relative to each female X-chromosome.
Our long term goal
is to define how genes are identified for coordinating regulation, the key initial step in their regulation.